Sick Building Syndrome: Tired and Stuffy? Think of Your House or Your Office.

BuildingSick building syndrome is a term coined to describe symptoms associated with a structure such as an office building or house. The illness is characterized by fatigue, headache and upper-respiratory symptoms (cough, scratchy sore throat, sinus problems, etc.) Although the symptoms usually resolve when a person leaves the offending structure symptoms can persist.
The lack of fresh air is associated with respiratory tract irritation, fatigue and headaches. An office building has numerous irritants, the most pernicious of which are volatile organic chemicals. Sources of irritants include off-gassing from carpet chemicals, copying machines, insecticides, cleaning compounds, etc. Engineers are aware of the need for fresh air and are required to provide a certain inflow from external air ducts. However, there is a great temptation to reduce the external air input in cold winter months or hot summer days in an effort to reduce energy consumption.
Additionally, air taken from outside vents isn’t necessarily “fresh air.” I have investigated building where the external air intake was very close to the exhaust of diesel trucks that unload supplies for the building.
Mold is an additional and quite severe cause of troublesome building-associated symptoms. It can often be suspected by the characteristic odor of mold and is often noted in buildings with excessive humidity or history of water leaks.
The emphasis on energy conservation that started in the 1970s and construction advances have resulted in buildings and homes that can be almost air-tight. Most new office buildings do not have windows that can be opened. Additionally, the modern home can have very little fresh air intake in hot or cold months when trying to save on heating or air conditioning costs.
There is no specific test for sick building syndrome. Definitely suspect this illness as a cause of upper-respiratory complaints that clear up after you leave the building. If you feel well on weekends and poorly during the work week a building with poor air quality might be the cause. Similarly, if you feel better when you are absent from your home and have a return of symptoms when living in the home an investigation into the air quality might be quite helpful.
A symptom that is more subtle that is more subtle than a typical building-associated cough or runny nose is fatigue. Of course, fatigue in the workplace or home can be due to innumerable physical or psychological causes. However, keep in mind that that poor air quality can cause serious fatigue.
Careful observation of symptoms, the timing of the symptoms and the location can help determine in an office building or home is the cause.

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Reappraising Vitamin D and Calcium Supplementation

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Recently the U.S. Preventive Services Task Force (USPSTF) issued a recommendation against routine daily supplementation with vitamin D and calcium in most circumstances. They conclude that there is adequate evidence demonstrating the taking 400 units of vitamin D and 1,000 mg of calcium does not prevent fractures in postmenopausal women. In addition, they note that the aforementioned supplementation does cause an increase in kidney stones and, therefore, is associated with harm.

It is unclear whether higher doses of vitamin D and calcium prevent fractures in men and postmenopausal women. Oddly, vitamin D supplementation is effective in preventing falls in community-dwelling adults aged 65 or older who are at risk for falls. The USPSTF does recommend vitamin D for this group.

Although the routine use of vitamin D and calcium supplements have been called into question the need for adequate levels of vitamin D in the body remains a constant. Those who lack enough vitamin D suffer from inadequate bone formation and, in addition, lack the beneficial effects of vitamin D on muscle strength and balance.

Obtaining vitamin D from dietary sources is best, just as we find that all vitamins are most effective when obtained from dietary sources. Good sources of vitamin D include: fatty fish and fortified foods, such as milk, yogurt and orange juice.

For individuals at risk for vitamin D deficiency supplementation is essential. This group would include the chronically ill, patients with intestinal malabsorption, pregnant women and those being evaluated for osteoporosis.

For now, the best approach might be to measure vitamin D levels in individuals at risk for vitamin D deficiency, including those mentioned above, older women, and women with risk factors for osteoporosis, and use vitamin D supplementation to bring the levels to normal.

Risk factors for osteoporosis include bone fracture, a family history of fractures or osteoporosis, smoking, excess alcohol consumption, malabsorption, the use of certain medications, sedentary life style and small body frame.

Lyme Disease: The Basics of Prevention

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Lyme disease is a tick-borne illness with a peak incidence in the eastern United States during the summer months of June, July and August. The late manifestations, such as arthritis, can appear at any time during the year. It is most common in the northeast and mid-Atlantic states (from Maine to Virginia), the Midwest (Minnesota, Wisconsin and Michigan) and on the west coast in northern California.

The ticks are carried by mice and deer and are more likely to infect when they are quite small (the size of a poppy seed.) When the ticks change and become larger they are less likely to transmit infection. Ticks are most commonly found on the underside of low-lying shrubs or grass, particularly between grass and forest. They are not common on well-cut lawns, such as a golf course. A tick can attach to a pet and then attach to a human, thereby transmitting the disease. If the tick is removed before it becomes large (engorged with blood) it is very unlikely to transmit Lyme disease.

If a tick is on the skin, but does not bite it cannot transmit disease. If a tick is removed within 48 hours the risk of transmission is quite small. The risk of transmission in one study where a tick was removed before it was engorged in an area where 15% of ticks carried Lyme disease was only 1%.

The best way to remove a tick is with tweezers or your fingers covered with some protection, such as a disposable rubber glove. It is important not to crush the tick. After removing the tick wash the area and your hands with soap and water.

Taking the antibiotic doxycycline to prevent Lyme disease makes sense only under certain conditions: that the tick is a deer tick; that the tick has been attached for more than 36 hours; that doxycycline can be started within 72 hours after the tick has been removed; that the tick bite has occurred in areas of the US where Lyme disease is common; and that the person does not have a contraindication to the use of doxycycline (a tetracycline.)

If a person cannot take doxycycline then no antibiotic should be prescribed as prophylaxis against developing Lyme disease after a suspicious tick bite. Doxycycline is usually given as a single 200 mg dose.
The time between a tick bite and the onset of Lyme disease symptoms is 2 to 3 weeks. The first manifestation is usually a rash. Lyme disease also can cause arthritis, neurological problems, heart conduction abnormalities and other problems. Unfortunately, it takes two weeks for antibodies to appear in the blood making a blood test for Lyme at the time of the tick bite useless.

Statins and Grapefruit

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If you’re taking a statin medication for your cholesterol, you have undoubtedly heard the warning against consuming grapefruits or grapefruit juice. This restriction also applies to a number of other medications including certain cardiovascular medications, anti-cancer agents, antibiotics, antidepressants and others. For a more detailed list and approximations about the extent of the interaction with particular medications click on to the following site: http://www.cmaj.ca/content/suppl/2012/11/26/cmaj.120951.DC1/grape-bailey-1-at.pdf.

The discovery of the interaction was serendipitous. Researchers noticed a higher drug concentration in certain test subjects than others when a medication was initially being tested. Those with an elevated drug level were eventually found to have also consumed grapefruit. Pomelo, lime and marmalade can also produce the same effects.

The compounds in grapefruit responsible for the effect are called furanocoumarins and act by blocking the enzymes in the intestines responsible for the degradation of certain medications. It only takes one glass of grapefruit juice to produce the maximum effect, an effect that persists for longer than 24 hours. Therefore, taking grapefruit juice at a time well-separated from the medication dose is ineffective in solving the problem.

How big an issue does this represent? That depends on a number of factors, particularly on how dependent the medication is on the enzyme that is blocked by the juice. Some medications have a wide “therapeutic range.” In other words, increased blood levels don’t represent much of a concern. On the other hand, some medications have a narrow therapeutic range, with increased concentrations causing serious problems.

Although most statins should not be taken in combination with grapefruit products Crestor (rosuvastatin) and Pravachol (pravastatin) are exceptions since they are not significantly metabolized by the enzyme blocked by grapefruit.

Aspirin and Disease Prevention

AspirinRecently the New York Times ran an op-ed entitled “The 2,000-Year-Old Wonder Drug” extolling the benefits of aspirin for a number of illnesses including cardiovascular disease and cancer. Although quite enthused about aspirin as a disease preventive, the author does advise medical consultation about the risks versus the benefits.

Is aspirin usually a good idea for middle-aged American? For those with known cardiovascular disease it usually is. However, one year ago a large study in the Archives of Internal Medicine did not show a reduction in cardiovascular or cancer deaths in patients without prior cardiovascular disease taking low-dose aspirin. A reduction in non-fatal heart attacks was noted. This benefit, however, was associated with a 30% increased risk of significant bleeding. The authors conclude against the routine use of aspirin for patients at low risk for cardiovascular disease.

More concerning, than the well-known risk of bleeding from the stomach or intestines, is the possibility of bleeding in the brain. Although the absolute risk of intracranial vessel bleeding is small (two hemorrhagic strokes per 10,000 patients taking aspirin) the consequences can be devastating.

Also, does aspirin prevent cancer? The evidence suggests that it is effective in preventing colon cancer and might be effective in preventing other cancers, although the evidence for the latter is less clear. The dose necessary to produce a statistically significant reduction in colon cancer is not certain, but some suggest that a full aspirin (325 mg) rather than low-dose aspirin (81 mg) might be needed.

The increased risk of bleeding associated with any dose of aspirin, and the possibility of greater risk with a higher dose, along with the very useful colon cancer prevention strategy of colonoscopy now in place caused the American Cancer Society not to recommend the routine use of daily aspirin to prevent colon cancer.

Patients at low risk for cardiovascular disease should consult their doctor before committing to a lifetime of daily low-dose aspirin. Low risk is defined as a patient whose 10-year absolute risk of a first coronary disease event is less than 10%. The doctor can calculate the risk by using a formula derived from the Framingham study of cardiovascular disease.

Aspirin is the wonder drug touted in the New York Times but, as usual in medical matters, every situation is different.

Chronic Lyme Disease

Lyme disease is usually divided into three stages: early localized disease, early disseminated disease and late Lyme disease. The first stage is characterized by the characteristic rash with or without systemic symptoms such as fever, body aches and joint pains. Early disseminated disease is characterized by rashes and/or neurologic symptoms and/or heart problems. Late Lyme disease is associated with arthritis, usually involving one or a few large joints, particularly the knee, and/or neurological problems. The neurological problems can involve the brain, the covering of the brain or a specific nerve possibly creating headaches, paralysis, or nerve pain. Arthritis symptoms, particularly if only the knee is involved, can appear to be a solitary problem, with no clue that the problem is caused by Lyme disease.

Early disseminated disease occurs weeks to several months after the initial infection from the tick bite. These symptoms can be the first manifestation of Lyme disease since 20% of people with the disease do not recall any rash and approximately 25% of people with the disease do not recall a tick bite.

Late Lyme disease occurs months to years after the tick bite and, as in the case with early disseminated Lyme disease, the history of a rash or tick bite might not be present or a history of having had the earlier stages of Lyme disease. The symptoms include arthritis, predominantly of the large joints, especially the knees. Neurological symptoms can also occur.

Symptoms usually resolve gradually, as they do in most infectious diseases, after a full course of antibiotics. Post-Lyme disease syndrome refers to symptoms such as headache, muscle pain, joint pain and fatigue that persist, but generally resolve after six months to one year.

A confusing issue develops when a person who has, by all accounts, been successfully treated for Lyme disease suffers continuing health problems that do not resolve with time. This situation has been termed chronic Lyme disease by some and is the subject of much dispute.

Briefly, certain doctors and advocacy groups maintain that, in these situations, the symptoms are caused by Lyme disease that failed to be eradicated by the standard treatments. Medical authorities counter that the persisting symptoms are due to another illness that, perhaps, was triggered by Lyme disease.

The “other illness” suggested is often either fibromyalgia or chronic fatigue syndrome. Both usually respond poorly to any one of a number of medications or treatments traditionally employed. Many, if not most, physicians suspect that fibromyalgia and chronic fatigue syndrome are, at the root, psychological problems.

You can imagine how frustrated a person feels who had been totally healthy, was bitten by a tick, became ill with Lyme disease, failed to improve after treatment, and is now told he has a psychological illness! Personally, I think that the development of symptoms compatible with fibromyalgia or chronic fatigue syndrome after Lyme disease is further proof that these illnesses are not psychological.

I suspect that chronic Lyme disease is not due to the persistence of the Lyme organism, but that the Lyme organism has triggered some other illness. Therefore, additional antibiotics directed at Lyme would be pointless, and possibly harmful.

What to do? It is necessary to search for other illness triggered by Lyme. I have seen cases where Lyme triggers an arthritic illness. What initially was arthritis caused by the Lyme organism is now arthritis caused by another arthritic disease, itself triggered by Lyme. Look closely at the blood for autoimmune markers. If the symptoms suggest arthritis get treatment for arthritis even in the absence of confirmatory blood tests.

Persisting fatigue with or without bodily pain is usually the most troubling symptom for patients with “chronic Lyme disease.” Long courses of antibiotics are ,almost always, fruitless. A more productive approach is to start fresh, evaluating each symptom as a new issue using standard, individualized treatments as needed. For instance, despite the patient’s firm belief that persisting Lyme infection is causing severe fatigue treating fatigue with medications known to improve it can be very worthwhile. A creative and unprejudiced approach, as usual in medicine, offers the best chance for success.

Is my tiredness normal or do I have a problem?

Most fatigue is normal, reflecting inadequate sleep, overwork or stress. Normal fatigue is usually relieved by a good night’s rest or, at most, a relaxing weekend. When this is not the case, conditions and illnesses that cause fatigue should be considered.

As common in medicine, history is most important. How long has the fatigue been going on? When the onset can be traced to a lifestyle change – different work schedule, new marriage, etc. – the answer usually relates to the change with causes such as inadequate relaxation or new stresses.

When is the fatigue most apparent? Weekday fatigue absent on weekends would certainly suggest factors such as stress and overwork. One caveat: most fatigue, whatever the cause, improves with a good, relaxing weekend but, if the fatigue is due to an illness, the fatigue might improve over the weekend but should not be entirely gone.

Weekday fatigue might be the result of “sick building syndrome,” an often overlooked cause. Most office buildings built since the 1970s are sealed making it impossible to open a window. If the HVAC does not provide enough fresh air the irritation from air contaminated by building chemicals, mold, etc. causes nasal and sinus symptoms with resulting fatigue.

What about fatigue that is more noticeable on the weekend than during the work week? It happens more often than you might think. Assuming that the weekend is not loaded with a stress that is less apparent than that noted during the week, several factors are often responsible.

Obviously too much socializing, partying and drinking could well be the cause, but these are usually obvious to the person. A more subtle reason for fatigue more apparent on the weekend than during the week is, oddly, too much sleep. Many people get an “overslept” sensation when they sleep in on a Saturday or Sunday.

Fatigue due to too much sleep is a curiosity noted more commonly in patients with allergies and sinus problems than it is in the general population. People with this condition need a fixed amount of sleep and should not sleep more than the usual required hours.

Other causes of weekend fatigue would include allergic exposure that does not occur during the week. Outdoor activities with resultant exposure to airborne allergens can cause fatigue as well as typical allergy symptoms.

Of course, too much alcohol on the weekend can cause fatigue. Sometimes the relationship isn’t obvious. Some individuals have an allergic response to alcohol, particularly red wine, producing fatigue the following day after amounts that were quite reasonable.

If I’m not fatigued on a vacation does that mean my fatigue is due to stress? Not necessarily. A change in climate is quite helpful for people with fatigue related to allergies. A person might be tired in a rainy area of the country that is laden with mold but feel quite good in the clean, dry desert. Additionally, there might be some airborne irritant present at home or in the office that’s not present in the vacation home or hotel room.

When trying to find an answer for the symptom of fatigue keeping a fatigue diary can be quite helpful. Noting any activities, sleep patterns or locations that improve fatigue can offer an important clue.